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KMID : 0545120110210050464
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Journal of Microbiology and Biotechnology
2011 Volume.21 No. 5 p.464 ~ p.469
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Ferric Reductase Activity of the ArsH Protein from Acidithiobacillus ferrooxidans
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Hongyu Mo
Qian Chen
Juan Du
Lin Tang
Fang Qin
Bo Miao
Xueling Wu
Jia Zeng
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Abstract
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The arsH gene is one of the arsenic resistance system in bacteria and eukaryotes. The ArsH protein was annotated as a NADPH-dependent flavin mononucleotide (FMN) reductase with unknown biological function. Here we report for the first time that the ArsH protein showed high ferric reductase activity. Glu104 was an essential residue for maintaining the stability of the FMN cofactor. The ArsH protein may perform an important role for cytosolic ferric iron assimilation in vivo.
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KEYWORD
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Acidithiobacillus ferrooxidans, ArsH, Flavoprotein, Ferric reductase
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